OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. Pereira RO, Tadinada SM, Zasadny FM, Oliveira KJ, Pires KMP, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED. EMBO J. 2017 Jun 12. pii: e201696179.

FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue. Markan KR, Naber MC, Small SM, Peltekian L, Kessler RL, Potthoff MJ. Mol Metab. 2017 Mar 27;6(6):602-610.

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans. Søberg S, Sandholt CH, Jespersen NZ, Toft U, Madsen AL, von Holstein-Rathlou S, Grevengoed TJ, Christensen KB, Bredie WLP, Potthoff MJ, Solomon TPJ, Scheele C, Linneberg A, Jørgensen T, Pedersen O, Hansen T, Gillum MP, Grarup N. Cell Metab. 2017 May 2;25(5):1045-1053.e6.

FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms. BonDurant LD, Ameka M, Naber MC, Markan KR, Idiga SO, Acevedo MR, Walsh SA, Ornitz DM, Potthoff MJ. Cell Metab. 2017 Apr 4;25(4):935-944.e4.

FGF21 and metabolic disease in 2016: A new frontier in FGF21 biology. Potthoff MJ. Nat Rev Endocrinol. 2017 Feb;13(2):74-76.

Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Kolb R, Phan L, Borcherding N, Liu Y, Yuan F, Janowski AM, Xie Q, Markan KR, Li W, Potthoff MJ, Fuentes-Mattei E, Ellies LG, Knudson CM, Lee MH, Yeung SJ, Cassel SL, Sutterwala FS, Zhang W. Nat Commun. 2016 Oct 6;7:13007.

Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, Sigmund CD, Grobe JL. Cell Rep. 2016 Aug 9;16(6):1548-60.

FAP finds FGF21 easy to digest. Gillum MP, Potthoff MJ. Biochem J. 2016 May 1;473(9):1125-7.

FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver. von Holstein-Rathlou, S., BonDurant, L., Peltekian, L., Naber, M. C., Yin, T. C., Claflin, K. E., Ibarra Urizar, A., Madsen, A. N., Ratner, C., Holst, B., Karstoft, K., Vandenbeuch, A., Anderson, C. B., Cassell, M. D., Thompson, A. P., Solomon, T. P., Rahmouni, K., Kinnamon, S. C., Pieper, A. A., Gillum, M. P. & Potthoff, M. J. Cell Metab. 23(2):335-343, 2016.

Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis. Markan KR, Potthoff MJ. Semin Cell Dev Biol. 2016 May;53:85-93.

Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis. Gray LR, Sultana MR, Rauckhorst AJ, Oonthonpan L, Tompkins SC, Sharma A, Fu X, Miao R, Pewa AD, Brown KS, Lane EE, Dohlman A, Zepeda-Orozco D, Xie J, Rutter J, Norris AW, Cox JE, Burgess SC, Potthoff MJ, Taylor EB. Cell Metab. 2015 Oct 6;22(4):669-81. 

Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis. McGlashon JM, Gorecki MC, Kozlowski AE, Thirnbeck CK, Markan KR, Leslie KL, Kotas ME, Potthoff MJ, Richerson GB, Gillum MP. Cell Metab. 2015 May 5;21(5):692-705.

Head over hepatocytes for FGF21. Potthoff MJ, Finck BN. Diabetes. 2014 Dec;63(12):4013-5. 

Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding. Markan KR, Naber MC, Ameka MK, Anderegg MD, Mangelsdorf DJ, Kliewer SA, Mohammadi M, Potthoff MJ. Diabetes. 2014 Dec;63(12):4057-63.

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Potthoff MJ, Potts A, He T, Duarte JA, Taussig R, Mangelsdorf DJ, Kliewer SA, Burgess SC. Am J Physiol Gastrointest Liver Physiol. 2013 Feb 15;304(4):G371-80.

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, Xiao G, Potthoff MJ, Wei W, Wan Y, Yu RT, Evans RM, Kliewer SA, Mangelsdorf DJ. Elife. 2012 Oct 15;1:e00065.

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Potthoff MJ, Kliewer SA, Mangelsdorf DJ. Genes Dev. 2012 Feb 15;26(4):312-24.

FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway. Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, Suino-Powell K, Xu HE, Gerard RD, Finck BN, Burgess SC, Mangelsdorf DJ, Kliewer SA. Cell Metab. 2011 Jun 8;13(6):729-38.

Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases. Moresi V, Williams AH, Meadows E, Flynn JM, Potthoff MJ, McAnally J, Shelton JM, Backs J, Klein WH, Richardson JA, Bassel-Duby R, Olson EN. Cell. 2010 Oct 1;143(1):35-45.

Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet. Sunny NE, Satapati S, Fu X, He T, Mehdibeigi R, Spring-Robinson C, Duarte J, Potthoff MJ, Browning JD, Burgess SC. Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1226-35.

FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, Goetz R, Mohammadi M, Finck BN, Mangelsdorf DJ, Kliewer SA, Burgess SC. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10853-8.

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. Montgomery RL, Potthoff MJ, Haberland M, Qi X, Matsuzaki S, Humphries KM, Richardson JA, Bassel-Duby R, Olson EN. J Clin Invest. 2008 Nov;118(11):3588-97.

MEF2: a central regulator of diverse developmental programs. Potthoff MJ, Olson EN. Development. 2007 Dec;134(23):4131-40.

Skeletal muscle remodeling. Potthoff MJ, Olson EN, Bassel-Duby R. Curr Opin Rheumatol. 2007 Nov;19(6):542-9.

Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Potthoff MJ, Arnold MA, McAnally J, Richardson JA, Bassel-Duby R, Olson EN. Mol Cell Biol. 2007 Dec;27(23):8143-51.

Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. Potthoff MJ, Wu H, Arnold MA, Shelton JM, Backs J, McAnally J, Richardson JA, Bassel-Duby R, Olson EN. J Clin Invest. 2007 Sep;117(9):2459-67.

Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Montgomery RL, Davis CA, Potthoff MJ, Haberland M, Fielitz J, Qi X, Hill JA, Richardson JA, Olson EN. Genes Dev. 2007 Jul 15;21(14):1790-802.