Recent Publications

Le TDV, Fathi P, Watters AB, Ellis BJ, Besing GK, Bozadjieva-Kramer N, Perez MB, Sullivan AI, Rose JP, Baggio LL, Koehler J, Brown JL, Bales MB, Nwaba KG, Campbell JE, Drucker DJ, Potthoff MJ, Seeley RJ, Ayala JE. Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets. Mol Metab. 2023 Jun;72:101718. doi: 10.1016/j.molmet.2023.101718. Epub 2023 Apr 7. PMID: 37030441; PMCID: PMC10131131.

Zhou B, Claflin KE, Flippo KH, Sullivan AI, Asghari A, Tadinada SM, Jensen-Cody SO, Abel T, Potthoff MJ. Central FGF21 Production Regulates Memory but Not Peripheral Metabolism. Cell Reports. 2022 Aug 23;40(8):111239. doi: 10.1016/j.celrep.2022.111239. https://pubmed.ncbi.nlm.nih.gov/36001982/

Claflin KE, Sullivan AI, Naber MC, Flippo KH, Morgan DA, Neff TJ, Jensen-Cody SO, Zhu Z, Zingman LV, Rahmouni K, Potthoff MJ. Pharmacological FGF21 Signals to Glutamatergic Neurons to Enhance Leptin Action and Lower Body Weight Through Increases in Energy Expenditure During Obesity. Molecular Metabolism. 2022 Aug 6;101564. doi: 10.1016/j.molmet.2022.101564. https://pubmed.ncbi.nlm.nih.gov/35944896/ 

Sullivan AI, Potthoff MJ, Flippo KH. Tany-seq: Integrated Analysis of the Mouse Tanycyte Transcriptome. Cells. 2022 May 10.

Flippo KH, Trammell SAJ, Gillum MP, Aklan I, Perez MB, Yavuz Y, Smith NK, Jensen-Cody SO, Zhou B, Claflin KE, Beierschmitt A, Fink-Jensen A, Knop FK, Palmour RM, Grueter BA, Atasoy D, Potthoff MJ. FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit. Cell Metab. 2022 Feb 1;34(2):317-328.e6. doi: 10.1016/j.cmet.2021.12.024. PMID: 35108517.

Claflin KE, Flippo KH, Sullivan AI, Naber MC, Zhou B, Neff TJ, Jensen-Cody SO, Potthoff MJ. Conditional gene targeting using UCP1-Cre mice directly targets the central nervous system beyond thermogenic adipose tissues. Mol Metab. 2021 Nov 26:101405. doi: 10.1016/j.molmet.2021.101405. Epub ahead of print. PMID: 34844020.

ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue. Sebag SC, Zhang Z, Qian Q, Li M, Zhu Z, Harata M, Li W, Zingman LV, Liu L, Lira VA, Potthoff MJ, Bartelt A, Yang L. Cell Rep. 2021 Nov 16;37(7):110003. doi: 10.1016/j.celrep.2021.110003. PMID: 34788615; PMCID: PMC8640996.

Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms. Sostre-Colón J, Uehara K, Garcia Whitlock AE, Gavin MJ, Ishibashi J, Potthoff MJ, Seale P, Titchenell PM. Cell Rep. 2021 May 18;35(7):109128. doi: 10.1016/j.celrep.2021.109128. PMID: 34010646; PMCID: PMC8167823.

OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21. Elife. Pereira RO, Marti A, Olvera AC, Tadinada SM, Bjorkman SH, Weatherford ET, Morgan DA, Westphal M, Patel PH, Kirby AK, Hewezi R, Bùi Trân W, García-Peña LM, Souvenir RA, Mittal M, Adams CM, Rahmouni K, Potthoff MJ, Abel ED. 2021 May 4;10:e66519. doi: 10.7554/eLife.66519. PMID: 33944779; PMCID: PMC8128440.

FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition. Reilly SM, Abu-Odeh M, Ameka M, DeLuca JH, Naber MC, Dadpey B, Ebadat N, Gomez AV, Peng X, Poirier B, Walk E, Potthoff MJ, Saltiel AR. J Clin Invest. 2021 May 17;131(10):e145546. doi: 10.1172/JCI145546. PMID: 33822771; PMCID: PMC8121507.